C. Sandoval Pacheco, A.M. Leroy, M. Derhourhi, T. Cardon, C. Leroy, N. Jouy, E. Com, B. Guevel, R. Bourette, J. Carrard, D. Barros, B. Duchêne, B. Toussaint, P. Froguel, N. Jonckheere, T. Chassat, I. Van Seuningen, R. Lavigne, C. Pineau, P. Pierre, F. Soncin, M. Salzet, A. Bonnefond and F. Lejeune. (2025) The readthrough molecule 2,6-diaminopurine promotes expression of endogenous neoantigens and an immune response against cancer cells. Molecular Therapy. https://doi.org/10.1016/j.ymthe.2025.09.024 (IF: 12)
S. Nedjma and F. Lejeune. (2025) Screening Methods for NMD Inhibitors or Readthrough Activators. Book Chapter in RNA Analysis, Methods and Protocols – Methods in Molecular Biology 2962:255-265.
L. Prochasson, M. Mghezzi-Habellah, A. Roisin, M. Palma, J.P. Robin, S. de Bossoreille, L. Sareoua, D. Cluet, M. Mouehli, D. Decimo, S. Réty, A. Desrames, T. Chaze, M. Matondo, H. Dutartre, M.I. Thoulouze, F. Lejeune, P. Jalinot, V. Mocquet. (2025) HTLV-1 Rex hijacks UPF1 in a CRM1 dependent manner, leading to NMD inhibition and revealing unexpected proviral roles of UPF1. Nucleic Acid Research 53(9). https://doi.org/10.1093/nar/gkaf434 (IF: 16.7).
N. Benslimane, C. Loret, P. Chazelas, F. Favreau, P.A. Faye, F. Lejeune and A.S. Lia. (2024). Readthrough Activators and Nonsense-Mediated mRNA Decay Inhibitor Molecules: Real Potential in Many Genetic Diseases Harboring Premature Termination Codons. Pharmaceuticals 17 (314). https://doi.org/10.3390/ph17030314 (IF: 5.2).
J. Carrard and F. Lejeune. (2023). Nonsense-mediated mRNA decay, a simplified view of a complex mechanism. BMB reports 56(12):625-632. Invited review. doi: 10.5483/BMBRep.2023-0190 (IF : 3.8).
J. Carrard, F. Ratajczak, J. Elsens, C. Leroy, R. Kong, L. Geoffroy, A. Comte, G. Fournet, B. Joseph, X. Li, S. Moebs-Sanchez and F. Lejeune. (2023). Identifying Potent Nonsense- Mediated mRNA Decay Inhibitors with a Novel Screening System. Biomedicines - https://doi.org/10.3390/biomedicines11102801 (IF: 4.7).
N. Benslimane, F. Miressi, C. Loret, L. Richard, A. Nizou, I. Pyromali, PA. Faye, F. Favreau, F. Lejeune and AS. Lia. (2023). Amlexanox: Readthrough Induction and Nonsense- Mediated mRNA Decay Inhibition in a Charcot–Marie–Tooth Model of hiPSCs-Derived Neuronal Cells Harboring a Nonsense Mutation in GDAP1 Gene. Pharmaceuticals (IF: 5.2)
C. Leroy, S. Spelier, N.C. Essonghe, V. Poix, R. Kong, P. Gizzi, C. Bourban, S. Amand, C. Bailly, R. Guilbert, D. Hannebique, P. Persoons, G. Arhant, A. Prévotat, P. Reix, D. Hubert, M. Gérardin, M. Chamaillard, N. Prevarskaya, S. Rebuffat, G. Shapovalov, J. Beekman and F. Lejeune. (2023). Use of 2,6-diaminopurine as a potent suppressor of UGA premature stop codons in cystic fibrosis. Molecular Therapy (IF: 12.91)
F. Lejeune. (2022). Nonsense-Mediated mRNA Decay, a Finely Regulated Mechanism. Biomedecines 10(1): 141 (IF: 6.0)
M. Palma, C. Leroy, S. Salomé-Desnoulez, E. Werkmeister, R. Kong, M. Mongy, H. Le Hir and F. Lejeune. (2021). A role for AKT1 in nonsense-mediated mRNA decay. Nucleic Acid Research 49(19):11022-11037 (IF: 16.97)
M. Palma and F. Lejeune. (2021). Deciphering the molecular mechanism of stop codon readthrough. Biol Rev Camb Philos Soc: doi: 10.1111/brv.12657 (IF: 12.82)
C. Trzaska, S. Amand, C. Bailly. C. Leroy, V. Marchand, E. Duvernois-Berthet, JM. Saliou, H. Benhabiles, E. Werkmeister, T. Chassat, R. Guilbert, D. Hannebique, A. Mouray, MC. Copin, PA. Moreau, E. Adriaenssens, A. Kulozik, E. Westhof, D. Tulasne, Y. Motorin, S. Rebuffat and F. Lejeune. (2020). 2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations. Nature Com. 11(1):1509. (IF: 14.919)
A. Bokhari, V. Jonchere, A. Lagrange, R. Bertrand, M. Svrcek, L. Marisa, O. Buhard, M. Greene, A. Demidova, J. Jia, E. Adriaenssens, T. Chassat, D.S. Biard, J.F. Flejou, F. Lejeune, A. Duval, A. Collura (2018). Targeting nonsense-mediated mRNA decay in colorectal cancers with microsatellite instability. Oncogenesis 7:70. (IF : 5.9)
H. Benhabiles, S. Gonzalez-Hilarion, S. Amand, C. Bailly, A. Prévotat, P. Reix, D. Hubert, E. Adriaenssens, S. Rebuffat, D. Tulasne and F. Lejeune. (2017). Optimized approach for the identification of highly efficient correctors of nonsense mutations in human diseases. Plos One 12: e0187930. (IF: 2.7)
F. Lejeune. Nonsense-mediated mRNA decay at the crossroads of many cellular pathways. (2017). BMB Rep. 50:175-185. Invited Review (IF: 3.1)
J. Jia, S. Gonzalez-Hilarion, E. Werkmeister, F. Lafont, D.C. Grunert, D. Tulasne and F. Lejeune. (2017). PTC readthrough in human cells occurs in novel cytoplasmic foci and requires UPF proteins. J. Cell Sci. 130:3009-3022. (IF: 4.5)
F. Lejeune. (2016). Triple effect of nonsense-mediated mRNA decay inhibition as a therapeutic approach for cancer. Single Cell Biology. 5:136. Invited Review
H. Benhabiles, J. Jia and F. Lejeune. (2016). Nonsense mutation correction in human diseases, an approach for targeted medicine. Ed. Elsevier Book: 1-192.
J. Jia, A. Furlan, S. Gonzalez-Hilarion, C. Leroy, D.C. Gruenert, D. Tulasne and F. Lejeune. (2015). Caspases shut down nonsense-mediated mRNA decay during apoptosis. Cell Death and Differentiation. 22:1754-1763. (IF: 10.7)
S. Gonzalez-Hilarion, T. Beghyn, N. Debreuck, K. Mamchaoui, V. Mouly, D.C. Gruenert, B. Deprez and F. Lejeune. (2012). Rescue of nonsense mutations by amlexanox in human cells. Orphanet Journal of rare Diseases 7:58. (IF: 5.7)
S. Apcher, C. Daskalogianni, F. Lejeune, B. Manoury, G. Imhoos, L. Heslop and R. Fahraeus (2011). Major source of antigenic peptides for the MHC class I pathway is produced during the pioneer round of mRNA translation. PNAS 108:11572-11577. (IF: 10.7)
N. Dreumont, C.F. Bourgeois, F. Lejeune, Y. Liu, D.J. Elliot and J. Stévenin (2010). Human RBMY regulates germline-specific splicing events by modulation the function of serine-arginine rich proteins 9G8 and Tra2beta. J. Cell Sci. 123:40-50. (IF: 4.5)
S. Durand, N. Cougot, F. Mahuteau-Betzer, CH. Nguyens, D. Grierson, E. Bertrand, J. Tazi, F. Lejeune (2007). Inhibition of nonsense-mediated mRNA decay (NMD) by a new chemical molecule reveals the dynamic of NMD factors in P-bodies. J Cell Biol. 178:1145-1160. (IF: 8.8)